Maintaining healthy cells is the key to experimental success and reproducible research results. Read 2 answers by scientists to the question asked by zeng. Databases ucsf guides at university of california, san. Powered by a wave of next generation sequence data, oncology is in the midst of a paradigm shift towards personalized medicine. How to use cancer cell line encyclopedia researchgate.
In order to generate such resource we constructed a novel comprehensive computational framework for the assessment of tumor suppressor functional status. The cancer cell line encyclopedia enables predictive. Cancer cell line encyclopedia five key discoveries seven. Human brain tumor cell lines cls cell lines service. Science here, at last, we have a definitive textbook specifically devoted to. Cancer cell international publishes articles on all aspects of cancer cell biology.
This experimental method, published online in nature cell biology, could in future be used to study certain tumours. Nextgeneration characterization of the cancer cell line. Ubc has a higher incidence in males than in females 3. The cancer cell line encyclopedia is a database of gene expression, genotype, and drug sensitivity data for human cancer cell lines.
Broadnovartis cancer cell line encyclopedia ccle ccle broad institute. Human brain tumor cell lines cls cell lines service part of the cls cell bank table 1. The systematic translation of cancer genomic data into knowledge of tumor biology and therapeutic avenues remains challenging. Access the ccle public project by selecting cancer cell line encyclopedia ccle from public projects in the top navigation bar. Cancer cell provides a highprofile forum to promote major advances in cancer research and oncology. Broadnovartis cancer cell line encyclopedia ccle cbioportal tcga. There is currently no content classified with this term. There is no comparable text in cancer biology nature the biology of cancer is no doubt the definitive statement on its topic today. Terminally differentiated noncancerous human cells can be reprogrammed in culture to exhibit characteristics usually associated with cancer stem cells, and promote tumour growth when injected into mice.
Cell biology can be described as the study of individual. Atsushi doi tcga, ccle, feature, tcga, the cancer genome atlas tcga. Tumor suppressors status in cancer cell line encyclopedia. Home about data contact login ccle logo broad logo. A172 1, 1 5 anaplastic glioma cell line homo sapiens human. This opens a popup window to share the url for this database. The journal focuses on cancer studies reporting data from biological. Praise for the first edition of the biology of cancer by robert a.
Cancer cell line encyclopedia this link opens in a new window. Description, the cancer cell line encyclopedia is a database of gene expression, genotype, and drug sensitivity data for human cancer cell lines. Trusted, compassionate information for people with cancer and their families and caregivers, from the american society of clinical oncology asco, the voice of the worlds. Origin and general characteristics name of cell line cell type organism, ethnicity age gender tissue disease morphology growth properties cls order no.
The cancer cell line encyclopedia project is a collaboration between the broad institute, and the novartis institutes for biomedical research and its genomics institute of the novartis research foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models, to develop integrated computational analyses that link distinct pharmacologic. The cancer cell line encyclopedia presents the first results from a largescale screen of some 947 cancer cell lines with 24 anticancer drugs, with the aim of identifying specific genomic. The broadnovartis cancer cell line encyclopedia ccle is an ongoing project from collaboration between the broad institute, and the novartis institutes for biomedical research and its genomics institute of the novartis research foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models, to develop integrated computational. The cancer cell line encyclopedia enables predictive modeling of. Here we describe the cancer cell line encyclopedia ccle. The ccle project is a collaboration between the broad institute of mit and harvard, and the novartis institutes for biomedical research and its genomics institute of the novartis research foundation.
The ccle cancer cell line encyclopedia project is a collaboration between the broad institute, and the novartis institutes for biomedical research and its genomics institute of the novartis research foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models, to develop integrated computational analyses that link. In the bottomright part of the project information box, click copy project. Predicting enzyme targets for cancer drugs by profiling human metabolic reactions in nci60 cell lines. The ubc40 urothelial bladder cancer cell line index. The related 2012 nature publication is titled the cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Urothelial bladder cancer ubc has a high incidence, with 3,696 new cases and 51,056 deaths from ubc in europe in 2011 and a high prevalence due to the fact that it is commonly an indolent disease. Nextgeneration characterization of the cancer cell line encyclopedia. We report systematically derived status of 69 known or putative tumor suppressors, across 799 samples of the cancer cell line encyclopedia.
Cancer cell line encyclopedia ccle the cgc knowledge. To give you confidence in the health of your cells every step of the way, weve highlighted the technologies and products within cell biology that are critical to maintaining optimal cell health. The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Together, this dataset and an accompanying public data portal provide a resource for the acceleration of cancer research using model cancer cell.